IL-33 Antibody

• Background :

  IL-33 Antibody: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1α /beta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP) . Receptor binding of IL-33 activates NF-κ B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.

• NCBI Gene ID :

  90865

• Swiss Prot :

  O95760

• Accession Number :

  NP_254274

• Host :

  Rabbit

• Reactivity :

  Human

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  IL-33 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1369 - Human Lymph node Tissue Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse: (72%)

• Buffer :

  IL-33 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  IL-33 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  IL33

• Positive Control 2 :

  Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide

• NCBI Official Name :

  Interleukin 33

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Schmitz J, Owyang A, Oldham E, et al. IL-33, and interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity2005; 23:479-90.

• Background Reference 02 :

  Dinarello CA. Interleukin-18, a proinflammatory cytokine. Eur. Cytokine Netw.2000; 11:483-6.

• Background Reference 03 :

  Brint EK, Xu D, Liu H, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol.2004; 5:373-9.

• Background Reference 04 :

  Chackerian AA, Oldham ER, Murphy EE, et al. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J. Immunol.2007; 179:2551-5.

• Other Product Names :

  IL-33 Antibody: DVS27, IL1F11, NF-HEV, NFEHEV, C9orf26, NFHEV, Interleukin-33, Interleukin-1 family member 11, IL-33

• Tested Applications :

  ELISA, WB, IF

• Protein ID :

  15559209

• Physical Properties :

  Liquid