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IL-27 Recombinant Protein

CAT: 0223-90-530Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0223-90-530Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naie CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development) . Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.
CAS Number
9000-83-3
NCBI Gene ID
50498
Swiss Prot
Q8VE43
Accession Number
NP_056581/AAI19403
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Chemokines & Cytokines
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Epstein-Barr virus induced gene 3
NCBI Organism
Mus musculus
Other Product Names
Interleukin-27
Species
Mouse
Protein ID
7657052
Physical Properties
Lyophilized

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