IL-27 non-lytic Recombinant Protein

• Background:

  Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naie CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development) . Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.

• NCBI Gene ID:

  10148

• Swiss Prot:

  P11672

• Accession Number:

  NP_005746/NP_663634

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Immunology, Other

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μ l sterile water. Add 1X PBS to the desired protein concentration.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Epstein-Barr virus induced 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Interleukin-27

• Species:

  Human

• Protein ID:

  14577917

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3