IGF II Recombinant Protein

• Background:

  Insulin-like growth factor 2 (IGF-2) is also known as Somatomedin-A, IGF-II, PP9974, and is one of three protein hormones that share structural similarity to insulin. IGF-2 exerts its effects by binding to the IGF-1 receptor. IGF2 may also bind to the IGF-2 receptor (also called the cation-independent mannose 6-phosphate receptor), which acts as a signalling antagonist; that is, to prevent IGF2 responses. The major role of IGF2 is as a growth promoting hormone during gestation. In the process of Folliculogenesis, IGF2 is created by Theca cells to act in an autocrine manner on the theca cells themselves, and in a paracrine manner on Granulosa cells in the ovary. IGF2 promotes granulosa cell proliferation during the follicular phase of the menstrual cycle, acting alongside Follicle Stimulating Hormone (FSH) . After ovulation has occurred, IGF-2 promotes progesterone secretion during the luteal phase of the menstrual cycle together with Luteinizing Hormone (LH) . Thus, IGF2 acts as a Co-hormone together with both FSH and LH. IGF-2 may play a key role in memory and could potentially be used to treat Alzheimer's Disease. It is sometimes produced in excess in islet cell tumours, causing hypoglycemia. Doege-Potter syndrome is a paraneoplastic syndrome in which hypoglycemia is associated with the presence of one or more non-islet fibrous tumors in the pleural cavity. has been shown to interact with IGFBP3 and Transferrin.

• NCBI Gene ID:

  3481

• Swiss Prot:

  P01344

• Accession Number:

  P01344-1

• Tag:

  N-Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Cell Cycle, Growth Factors, Signal Transduction

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  50 mM tris, 100 mM glycine, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  35 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Insulin-like growth factor 2 (somatomedin A)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  MacRae, Fiona , 2011, Daily Mail (London) .

• Background Reference 02:

  Balduyck B, et al., 2006, J Thorac Oncol 1 (6) : 588–90.

• Background Reference 03:

  Storch, S, et al., 2001, FEBS Lett. (Netherlands) 509 (3) : 395–8.

• Background Reference 04:

  Buckway, C K, et al., 2001, J. Clin. Endocrinol. Metab. (United States) 86 (10) : 4943–50.

• Other Product Names:

  IGF2, C11orf43, FLJ22066, FLJ44734, IGF-II, PP9974

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3