ILDR2 Recombinant Protein

• Background:

  ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.

• NCBI Gene ID:

  387597

• Swiss Prot:

  Q71H61

• Accession Number:

  NP_955383.1

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Chemokines & Cytokines, Immunology, Infectious Disease, Neuroscience, Signal Transduction, Stem Cell

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  45.1 kDa

• Applications Notes:

  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

• NCBI Official Name:

  Immunoglobulinlikedomaincontainingreceptor2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Elizabeth J Millings, et al. PLoS One. 2018. 13 (5) :e0197548.

• Background Reference 02:

  Joseph R Podojil, et al. J Immunol. 2018. 200 (6) :2013-2024.

• Background Reference 03:

  Iris Hecht, et al. J Immunol. 2018. 200 (6) :2025-2037.

• Other Product Names:

  ILDR2, C1orf32

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3