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IL-4 Recombinant Protein

CAT: 0223-40-604Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-40-604Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues.
CAS Number
9000-83-3
NCBI Gene ID
3565
Swiss Prot
P05112
Accession Number
NP_000580.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Signal Transduction
Purity
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized IL-4 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IL-4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Interleukin 4
NCBI Organism
Homo sapiens
Other Product Names
BSF1, IL-4, BCGF1, BSF-1, BCGF-1, Interleukin-4, B-cell stimulatory factor 1
Species
Human
Protein ID
4504669
Physical Properties
Lyophilized

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