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HGF Recombinant Protein

CAT: 0223-11-302Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-302Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Hepatocyte growth factor (HGF) is a paracrine cellular growth, motility and morphogenic factor. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. In addition, HGF has been implicated in a variety of cancers, including of the lungs, pancreas, thyroid, colon, and breast.
CAS Number
9000-83-3
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
81.6 kDa (53.7 kDa|27.9 kDa)
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The mature form of HGF is a disulfide-linked heterodimer composed of proteolytically cleaved α and β chain. The protein has a calculated MW of 81.6 kDa (α chain 53.7 kDa and β chain 27.9 kDa) . Th
Background Reference 01
Johnson M, et al. Hepatology. 1993. 17 (6) :1052-61.
Background Reference 02
Bottaro DP, et al. Science. 1991. 251 (4995) :802-4.
Background Reference 03
Stamos J, et al. EMBO J. 2004. 23 (12) :2325-35.
Other Product Names
HGF, HPTA, SF
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized

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