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HGF Antibody

CAT: 0223-59-064Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-064Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. Transcript Variant: This variant (1) encodes the longest isoform (1) . To date, experimental evidence for cleavage of the proprotein into two mature chains has been shown only for isoform 1.
NCBI Gene ID
3082
Swiss Prot
P14210
Accession Number
P14210
Host
Rabbit
Reactivity
Human
Immunogen
This HGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-554 amino acids from the C-terminal region of human HGF.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
83 kDa
Fragment
Rabbit Ig
Symbol
HGF
NCBI Official Name
Hepatocyte growth factor
NCBI Organism
Homo sapiens
Background Reference 01
Ryugo, M., et al., Transplantation 78 (8) :1153-1158 (2004) .
Background Reference 02
Lyon, M., et al., J. Biol. Chem. 279 (42) :43560-43567 (2004) .
Background Reference 03
He, Y., et al., World J. Gastroenterol. 10 (19) :2827-2830 (2004) .
Background Reference 04
Tjin, E.P., et al., Blood 104 (7) :2172-2175 (2004) .
Other Product Names
Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain, HGF, HPTA
Tested Applications
WB, IHC-P, Flow
Protein ID
123116
Physical Properties
Liquid

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