TIM-3 Recombinant Protein

CAT: 0223-97-027Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-97-027Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1) -mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
CAS Number
9000-83-3
NCBI Gene ID
171285
Swiss Prot
AAL65156.1
Accession Number
AAL65156.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
21 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
T cell immunoglobulin mucin-3
NCBI Organism
Mus musculus
Background Reference 01
Monney, L. et al., 2002, Nature. 415: 536-41.
Background Reference 02
Sabatos, CA. et al., 2003, Nat. Immunol. 4: 1102-10.
Background Reference 03
Anderson, AC. et al., 2006, Curr. Opin. Immunol. 18: 665-9.
Other Product Names
HAVCR2, TIM3, TIMD3, FLJ14428, KIM3
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized

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