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FOLR2 Recombinant Protein

CAT: 0223-11-182Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-182Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
CAS Number
9000-83-3
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology, Obesity, Signal Transduction
Purity
>90% as determined by SDS-PAGE.
Buffer
50 mM Tris, 100 mM Glycine, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
26.5 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.5 kDa. The protein migrates as 33-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background Reference 01
Ratnam, M. et al., 1989, Biochemistry, 28 (20) :8249-54.
Background Reference 02
Ross, J.F. et al., 1999, Cancer, 85:348.
Background Reference 03
Reddy, J.A. et al., 1999, Blood, 93:3940.
Background Reference 04
Ross, J.F. et al.,1994, Cancer 73:2432.
Other Product Names
FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, FBP
Tested Applications
WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized

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