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FOLR2 Antibody

CAT: 0223-58-204Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-204Size:400 µL
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Background
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.
NCBI Gene ID
2350
Swiss Prot
P14207
Accession Number
P14207
Host
Rabbit
Reactivity
Human
Immunogen
This FOLR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human FOLR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FOLR2
NCBI Official Name
Folate receptor beta
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
O'Byrne, M.R., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (8) :689-694 (2010)
Background Reference 03
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Background Reference 04
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Other Product Names
Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2
Tested Applications
WB
Protein ID
116241366
Physical Properties
Liquid

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