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FGF2 Recombinant Protein

CAT: 0223-91-034Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-034Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysaccharides and lipids with lower affinity. Expression of FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively mild phenotype, suggesting compensation by other FGF family members. FGF basic modulates such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, neuronal function and neural degeneration. Transgenic overexpression of FGF basic results in excessive proliferation and angiogenesis is reminiscent of a variety of pathological conditions.
CAS Number
9000-83-3
NCBI Gene ID
14173
Swiss Prot
P15655
Accession Number
P15655
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 400mM NaCl, pH 7.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
17.15 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Fibroblast growth factor 2
NCBI Organism
Mus musculus
Other Product Names
Fibroblast Growth Factor 2, FGF-2, Basic Fibroblast Growth Factor, bFGF, Heparin-Binding Growth Factor 2, HBGF-2, Fgf2, FGFb, FGF basic
Species
Mouse
Physical Properties
Lyophilized

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