FGF1 Recombinant Protein

• Background:

  Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent growth factor for fibroblasts and endothelial cells. FGF acidic is involved in wound repair, angiogenesis, and development. FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism. The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling. There are four distinct FGF receptors and each has multiple splice variants. FGF acidic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLCγ/PKC, and PI3K/Akt pathways.

• NCBI Gene ID:

  2246

• Swiss Prot:

  P05230

• Accession Number:

  NP_000791

• Tag:

  Tag free

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Growth Factors

• Purity:

  >98% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  15.8 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Fibroblast growth factor 1 (acidic)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Powers, C.J. et al., 2000, Endocr Relat Cancer 7, 165-97.

• Background Reference 02:

  Prudovsky, I. et al., 2003, J Cell Sci 116, 4871-81.

• Background Reference 03:

  Ornitz, D.M. and Itoh, N., 2001, Genome Biol 2, REVIEWS3005.

• Background Reference 04:

  Mohammadi, M. et al., 2005, Curr Opin Struct Biol 15, 506-16.

• Other Product Names:

  FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3