FGF1 Recombinant Protein

• Background:

  FGF acidic, also known as ECGF, FGF-1and HBGF-1, is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal, ectodermal, and endodermal origin. Its association with heparan sulfate is a prerequisite for activation of FGF receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta, exported to the cytosol, dephosphorylated, and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.

• NCBI Gene ID:

  2246

• Swiss Prot:

  P05230

• Accession Number:

  P05230

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Growth Factors

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 20mM Tris, 400mM NaCl, 1mM DTT, pH 8.0 . It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  15.9 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Fibroblast growth factor 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Fibroblast Growth Factor 1, FGF-1, Acidic Fibroblast Growth Factor, aFGF, Endothelial Cell Growth Factor, ECGFHeparin-Binding Growth Factor 1, HBGF-1, FGF1, FGFA, FGF acidic

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3