EPHB4 Recombinant Protein

• Background:

  Ephrin type-B receptor 4 (EPHB4) is also known as HTK, MYK1 and TYRO11, is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.

• NCBI Gene ID:

  2050

• Swiss Prot:

  P54760

• Accession Number:

  NP_004435.3

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purity:

  >97% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  57.8 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  EPH receptor B4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bennett, B.D. et al., 1994, J. Biol. Chem. 269: 14211-14218.

• Background Reference 02:

  Noren, N.K. et al., 2006, Nat. Cell. Biol. 8: 815-825.

• Background Reference 03:

  Xia, G. et al., 2005, Cancer Res. 65: 4623-4632.

• Background Reference 04:

  Kertesz, N. et al., 2006, Blood. 107: 2330-2338.

• Other Product Names:

  EphB4, HTK, MYK1, TYRO11

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3