EphB4 Antibody

• Background:

  Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

• NCBI Gene ID:

  2050

• Swiss Prot:

  P54760

• Accession Number:

  P54760

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EphB4 antibody is generated from rabbits immunized with human recombinant EphB4 protein.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  108 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  EPHB4

• NCBI Official Name:

  Ephrin type-B receptor 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Steinle, J.J., et al., J. Biol. Chem. 277 (46) :43830-43835 (2002) . Suenobu, S., et al., Biochem. Biophys. Res. Commun. 293 (3) :1124-1131 (2002) . Wang, Z., et al., Blood 99 (8) :2740-2747 (2002) . Wilson, M.D., et al., Nucleic Acids Res. 29 (6) :1352-1365 (2001) . Wilkinson, D.G., Nat Rev Neurosci 2 (3) :155-164 (2001) .

• Other Product Names:

  Ephrin type-B receptor 4, Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, EPHB4, HTK, MYK1, TYRO11

• Tested Applications:

  WB, IHC-P

• Protein ID:

  19860819

• Physical Properties:

  Liquid