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CLEC10A Recombinant Protein

CAT: 0223-91-524Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-524Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc) . Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.
CAS Number
9000-83-3
NCBI Gene ID
10462
Swiss Prot
Q8IUN9
Accession Number
Q8IUN9
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
29.8 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
C-type lectin domain family 10 member A
NCBI Organism
Homo sapiens
Other Product Names
C-Type Lectin Domain Family 10 Member A, C-Type Lectin Superfamily Member 14, Macrophage Lectin 2, CD301, CLEC10A, CLECSF13, CLECSF14, HML
Species
Human
Protein ID
929654682
Physical Properties
Lyophilized

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