CLEC12A / MICL / CLL-1 Recombinant Protein

• Background:

  CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.

• NCBI Gene ID:

  160364

• Swiss Prot:

  Q5QGZ9

• Accession Number:

  NP_612210.4

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  50.2 kDa

• Applications Notes:

  This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 50.2 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  C-type lectin domain family 12 member A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Toft-Petersen M, et al. 2016. Br J Haematol. 175 (3) :393-401.

• Background Reference 02:

  Neumann K, et al. 2014. Immunity. 40 (3) :389-99.

• Background Reference 03:

  Chen CH, et al. 2006. Blood. 107 (4) :1459-67.

• Other Product Names:

  CLEC12A, MICL, CLL-1, CLL1, DCAL2, DCAL-2, CD371

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3