CD40 Recombinant Protein

• Background:

  CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

• NCBI Gene ID:

  958

• Swiss Prot:

  Q9UBH0

• Accession Number:

  P25942

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Apoptosis, Immunology, Neuroscience, Signal Transduction, Stem Cell, Other

• Concentration:

  1mg/ml after reconstitution.

• Buffer:

  Contains PBS. Reconstitute with 50 μ l sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 6 months after receipt when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  CD40 molecule, TNF receptor superfamily member 5

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Tumor Necrosis Factor Receptor Superfamily Member 5, TNFRSF5, CD40L Receptor

• Species:

  Human, Mouse

• Protein ID:

  4507581

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3