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CD40 / TNFRSF5 Recombinant Protein

CAT: 0223-11-496Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-496Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines.
CAS Number
9000-83-3
NCBI Gene ID
958
Swiss Prot
P25942
Accession Number
NP_001241.1
Tag
Mouse IgG Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
46.1 kDa
Applications Notes
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 46.1 kDa. The protein migrates as 58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
CD40 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Banchereau, J. et al., 1994, Annu. Rev. Immunol. 12: 881-922.
Background Reference 02
Ni, C.Z. et al., 2000, Proc. Natl. Acad. Sci. U.S.A. 97: 10395-10399.
Background Reference 03
Ferrari.S. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 12614-12619.
Background Reference 04
Bhushan, A and Covey, L.R. 2001, Immunol. Res. 24: 311-324.
Other Product Names
CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized

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