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Siglec-3 Recombinant Protein

CAT: 0223-91-401Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-401Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs) . Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. CD33 related Siglecs have differential expression pattern within the hematopoietic system. They are involved in the regulation of cellular activation within the immune system. Siglec 3 expression is restricted to cells of myelomonocytic lineage. Siglec3 recruits SHP1 and SHP2 to its ITIMs upon phosphorylation.
CAS Number
9000-83-3
NCBI Gene ID
945
Swiss Prot
P20138
Accession Number
P20138
Tag
C-Fc-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Stem Cell
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 2mM EDTA, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
55.01 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
CD33 molecule
NCBI Organism
Homo sapiens
Other Product Names
Myeloid Cell Surface Antigen CD33, Sialic Acid-Binding Ig-Like Lectin 3, Siglec-3, gp67, CD33, SIGLEC3
Species
Human
Physical Properties
Lyophilized

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