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Siglec-10 Recombinant Protein

CAT: 0223-11-190Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-190Size:0.1 mg
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Background
The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
CAS Number
9000-83-3
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
25 mM MES, 150 mM NaCl, pH5.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
60.2 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.2 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Background Reference 01
Whitney G., et al. 2001, Eur J Biochem., 268 (23), 6083-96.
Background Reference 02
Kivi E., et al. 2009, Blood., 114 (26), 5385-92.
Background Reference 03
Munday J., et al. 2001, Biochem J., 355 (Pt 2), 489-97.
Other Product Names
SIGLEC10, MGC126774, PRO940, Siglec10, SLG2
Tested Applications
WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized

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