CD58 Recombinant Protein

• Background:

  CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3) . CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.

• NCBI Gene ID:

  965

• Swiss Prot:

  Q9BRW0

• Accession Number:

  AAH05930

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  48.1 kDa

• Applications Notes:

  This recombinant protein can be used for E, WB. For research use only.

• NCBI Official Name:

  CD58 protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Barbosa JA., et al., 1986, J. Immunol. 136 (8) : 3085–91.

• Background Reference 02:

  Wang JH., et al., 1999, Cell 97 (6) : 791–803.

• Background Reference 03:

  De Jager PL., et al., 2009, Proc Natl Acad Sci U S A. 106 (13) : 5264–9.

• Other Product Names:

  CD58, LFA3, Ag3

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3