Biglycan Recombinant Protein

• Background:

  Biglycan is a 200-350 kD proteoglycan consisting of a 45 kD core protein and two chrondroitin/dermatan sulfate glycosaminoglycan chains. Biglycan binds to TGF-ß. It also binds to collagen type I in low ionic strength (less than 3 mM phosphate) buffer. At higher ionic strengths, Biglycan does not bind to collagen type I. It enhances the inhibition effect of TGF-ß on osteoclast proliferation at a concentration of 4-20 mg/ml. It also prevents the attachment of CHO cells to fibronectin, with a 50% inhibition at 17-21 mg/ml.

• NCBI Gene ID:

  633

• Swiss Prot:

  P21810

• Accession Number:

  P21810

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer, Signal Transduction

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  40.47 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Biglycan

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Biglycan, Bone/Cartilage Proteoglycan I, PG-S1, BGN, SLRR1A

• Species:

  Human

• Protein ID:

  578877726

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3