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Siglec-2 / CD22 Recombinant Protein

CAT: 0223-11-455Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-455Size:0.1 mg
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Background
B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
CAS Number
9000-83-3
NCBI Gene ID
12483
Swiss Prot
P35329
Accession Number
P35329.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
78.3 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 78.3 kDa. The protein migrates as 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
CD22 antigen
NCBI Organism
Mus musculus
Background Reference 01
Hatta Y., et al., 1999, Immunogenetics 49:280-286.
Background Reference 02
Doody G.M., et al., 1995, Science 269:242-244.
Background Reference 03
Tuscano J.M., et al., 1996, Eur. J. Immunol. 26:1246-1252.
Other Product Names
CD22, SIGLEC2, BL-CAM, SIGLEC-2, Siglec2, SIGLEC2FLJ22814
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized

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