ABCB5 Recombinant Protein

CAT: 0223-92-176Size: 0.05 mgDry Ice: NoHazardous: No
CAT#:0223-92-176Size:0.05 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ATP-binding cassette sub-family B member 5 (ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.
CAS Number
9000-83-3
NCBI Gene ID
340273
Swiss Prot
Q2M3G0
Accession Number
Q2M3G0
Tag
N-Trx tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Signal Transduction, Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
29.4 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
ATP binding cassette subfamily B member 5
NCBI Organism
Homo sapiens
Other Product Names
ATP-binding cassette sub-family B member 5, P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5
Species
Human
Physical Properties
Lyophilized

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