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MTCH2 Recombinant Protein

CAT: 0223-95-118Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-95-118Size:0.05 mg
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Background
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1) . The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3) . MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals (4-6), suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway. The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence.
CAS Number
9000-83-3
NCBI Gene ID
56428
Swiss Prot
Q791V5
Accession Number
NP_055157
Tag
Fusion Partner:
Type
Recombinant Proteins
Source
E. coli
Field of Research
Apoptosis
Purity
~95%
Buffer
1X PBS containing 0.1% SDS
Shipping Conditions
Dry Ice
Storage Conditions
Store in working aliquots at -70˚ C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Calculated Molecular Weight
19 kDa (Calculated)
Applications Notes
This recombinant protein can be used for WB and ELISA. For research use only.
NCBI Official Name
Mitochondrial carrier homolog 2 (C. elegans)
NCBI Organism
Mus musculus
Background Reference 01
Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
Background Reference 02
Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
Background Reference 03
Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.
Background Reference 04
Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol. 2005; 25:4579-90.
Other Product Names
MTCH2 Recombinant Protein: HSPC032, 2310034D24Rik, 4930539J07Rik, Mitochondrial carrier homolog 2
Tested Applications
ELISA, WB
Species
Mouse
Protein ID
5815347
Physical Properties
Liquid

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