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AGER Recombinant Protein

CAT: 0223-91-379Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-379Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Advanced Glycosylation End Product-Specific Receptor (AGER) belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serve as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
CAS Number
9000-83-3
NCBI Gene ID
177
Swiss Prot
Q15109
Accession Number
Q15109
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cell Cycle, Neuroscience
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
35.2 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Advanced glycosylation end product-specific receptor
NCBI Organism
Homo sapiens
Other Product Names
Advanced Glycosylation End Product-Specific Receptor, Receptor for Advanced Glycosylation End Products, AGER, RAGE
Species
Human
Physical Properties
Lyophilized

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