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ACVR2B Recombinant Protein

CAT: 0223-96-009Size: 0.2 mgDry Ice: NoHazardous: No
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CAT#:0223-96-009Size:0.2 mg
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Background
Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) .
CAS Number
9000-83-3
NCBI Gene ID
93
Swiss Prot
Q13705
Accession Number
NP_001097
Tag
C-His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>97% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
14.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Activin A receptor, type IIB
NCBI Organism
Homo sapiens
Background Reference 01
Attisano, L. et al., 1996, Mol. Cell. Biol. 16: 1066-1073.
Background Reference 02
Woodruff, T.K., 1998, Biochem. Pharmacology 55:953.
Other Product Names
ACVR2B, ACTRIIB, MGC116908
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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