Products for Research Use Only

4HPPD Recombinant Protein

CAT: 0223-92-016Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-92-016Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydroxyphenylpyruvate to homogentisate. 4HPPD exists in homodimer forms, which uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. When the active 4HPPD enzyme concentration is low in the human body, it results in high levels of tyrosine concentration in the blood, which can cause mild mental retardation at birth, and degradation in vision as a patient grows older.
CAS Number
9000-83-3
NCBI Gene ID
3242
Swiss Prot
P32754
Accession Number
P32754
Tag
N-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cell Cycle, Obesity, Signal Transduction
Buffer
Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 50mM NaCl, 1mM DTT, 0.1mM PMSF, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
47.1 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
4-hydroxyphenylpyruvate dioxygenase
NCBI Organism
Homo sapiens
Other Product Names
4-Hydroxyphenylpyruvate Dioxygenase, 4-Hydroxyphenylpyruvic Acid Oxidase, 4HPPD, HPD, HPPDase, PPD
Species
Human
Physical Properties
Liquid