GS-6620

• Description:

  GS-6620 is potent and selective HCV inhibitor. GS-6620 inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM. GS-6620 can be used for the researches of infection and inflammation, such as Hepatitis C Virus (HCV) [1][2].

• UNSPSC:

  12352005

• Target:

  HCV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/gs-6620.html

• Purity:

  98.93

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC=NN2C1=CC=C2[C@@]3 (C#N) [C@@] (O) (C) [C@H] (OC (C (C) C) =O) [C@@H] (CO[P@] (OC4=CC=CC=C4) (N[C@@H] (C) C (OC (C) C) =O) =O) O3

• Molecular Formula:

  C29H37N6O9P

• Molecular Weight:

  644.61

• References & Citations:

  [1]Joy Y Feng, et al. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrob Agents Chemother. 2014;58 (4) :1930-42.|[2]Cho A, et al. Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. J Med Chem. 2014 Mar 13;57 (5) :1812-25.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  1350735-70-4