GS-9770

• UNSPSC Description:

  GS-9770 is an orally active inhibitor for HIV protease with Ki of 0.16 nM. GS-9770 exhibits antiviral activity aginst HIV-1 strains and HIV-2 strains with EC50 of 1.9-26 nM, and 26 nM. GS-9770 is metabolic stable in human liver microsomes. GS-9770 exhibits good pharmacokinetic characters in Sprague Dawley rats[1].

• Target Antigen:

  HIV Protease

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/gs-9770.html

• Smiles:

  CC(C(F)(F)F)(C[C@@]1(C2=CC=C(C=C2)C3=NN(N=C3)C4CC4)C(N(C(N1)=N)[C@@H](C5=CC=C(C(C6=NC=NN6C(F)F)=C5)Cl)COC(NC7(C(F)F)CC7)=O)=O)C

• Molecular Weight:

  811.15

• References & Citations:

  [1]Mulato A, et al., Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0137323.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2306328-43-6