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GS-8873

CAT: 0804-HY-145713Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145713Size:1 Each
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Description
GS-8873 is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC50 of 4 nM. GS-8873 exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 causes neurofunctional deficits in rats and cynomolgus monkeys[1][2].
CAS Number
2241575-59-5
Product Name Alternative
HBV-IN-19
UNSPSC
12352005
Target
HBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gs-8873.html
Solubility
10 mM in DMSO
Smiles
COCC1=C(OCCCOC)C=C([C@]2([H])N(C(C)(CC2)C)N3C4=CC(C(C(O)=O)=C3)=O)C4=C1
Molecular Formula
C24H30N2O6
Molecular Weight
442.50
References & Citations
[1]Evangelos Aktoudianakis, et al. Compounds for the treatment of hepatitis b virus infection.WO2018144605A1.|[2]Kato D, et al., Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873. ACS Med Chem Lett. 2024 Mar 22;15 (4) :546-554.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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