GS-493

• Description :

  GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity[1].

• UNSPSC :

  12352005

• Target :

  Phosphatase; SHP1; SHP2

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/gs-493.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(C1=CC=C(N/N=C2C(C3=CC=C([N+]([O-])=O)C=C3)=NN(C4=CC=C([N+]([O-])=O)C=C4)C/2=O)C=C1)(O)=O

• Molecular Formula :

  C21H14N6O8S

• Molecular Weight :

  510.44

• References & Citations :

  [1]Grosskopf S, et al. Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo. ChemMedChem. 2015;10 (5) :815-826.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1710337-31-7]