GS-493

• UNSPSC Description:

  GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity[1].

• Target Antigen:

  Phosphatase; SHP2

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gs-493.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(C1=CC=C(N/N=C2C(C3=CC=C([N+]([O-])=O)C=C3)=NN(C4=CC=C([N+]([O-])=O)C=C4)C/2=O)C=C1)(O)=O

• Molecular Weight:

  510.44

• References & Citations:

  [1]Grosskopf S, et al. Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo. ChemMedChem. 2015;10(5):815-826.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1710337-31-7