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Dimethyl malonate

CAT: 0804-HY-Y1787-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Y1787-01Size:500 mg
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Description
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH) . Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1].
CAS Number
108-59-8
UNSPSC
12352211
Hazard Statement
H227, H319
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dimethyl-malonate.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(OC)CC(OC)=O
Molecular Formula
C5H8O4
Molecular Weight
132.11
Precautions
H227, H319
References & Citations
[1]Xu J, et al. Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest. Neuroscience. 2018 Nov 21;393:24-32.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
No Development Reported

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