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Bopindolol (malonate)

CAT: 0804-HY-B1562B-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1562B-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bopindolol ((±) -Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol. Bopindolol malonate can be used for essential and renovascular hypertension research.
CAS Number
82857-38-3
Product Name Alternative
(±) -Bopindolol (malonate)
UNSPSC
12352005
Hazard Statement
H302, H332
Target
5-HT Receptor; Adrenergic Receptor; Renin
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bopindolol-malonate.html
Purity
98.30
Solubility
10 mM in DMSO
Smiles
CC(N1)=CC2=C1C=CC=C2OCC(OC(C3=CC=CC=C3)=O)CNC(C)(C)C.O=C(O)CC(O)=O
Molecular Formula
C26H32N2O7
Molecular Weight
484.54
Precautions
H302, H332
References & Citations
[1]Harron DW, et al. Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1991 Jan;41 (1) :130-49.|[2]H Tanaka, et al. Hypotensive effect of bopindolol in pithed rats. Gen Pharmacol. 1993 Mar;24 (2) :373-5.|[3]Y Hosohata, et al. Bopindolol is a slowly dissociating beta 1-adrenoceptor antagonist when compared to other beta-blockers. Biol Pharm Bull. 1995 Aug;18 (8) :1066-71.|[4]Nagatomo T, et al. Bopindolol: pharmacological basis and clinical implications. Cardiovasc Drug Rev. 2001 Spring;19 (1) :9-24.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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