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VTP-27999 (TFA)

CAT: 0804-HY-50769-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-50769-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VTP-27999 TFA is an alkyl amine Renin inhibitor; VTP-27999 TFA is useful for Hypertension and End-Organ Diseases.
CAS Number
1013937-63-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vtp-27999-2,2,2-trifluoroacetate.html
Purity
97.00
Solubility
Ethanol : 2.4 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
O=C(O)C(F)(F)F.COC(NCCO[C@@H](C1=CC(Cl)=CC=C1)[C@@]2([H])CN(CCC2)C(NC[C@@H](NC)C[C@H]3CCCOC3)=O)=O
Molecular Formula
C28H42ClF3N4O7
Molecular Weight
639.10
Precautions
H302, H315, H319, H335
References & Citations
[1]New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61 (5) :1075-1082.|[2]Lanqi Jia? et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751|[3]Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52 (8) :2089-97. Epub 2012 Jul 25.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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