PF-06465469

• UNSPSC Description:

  PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM[1].

• Target Antigen:

  Itk

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pf-06465469.html

• Purity:

  99.48

• Solubility:

  DMSO : 11 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC=C(C(C)C)C(C)=C1)C2=CC=CC(C3=NN([C@H]4CN(C(C=C)=O)CCC4)C5=NC=NC(N)=C53)=C2

• Molecular Weight:

  523.63

• References & Citations:

  [1]Mamand S, et al. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep. 2018 Sep 21;8(1):14216.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1407966-77-1