(S,S,S)-AHPC (hydrochloride)

• Product Name Alternative:

  (S,S,S)-VH032-NH2 (hydrochloride)

• UNSPSC Description:

  (S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC (Compound 27) is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein[1].

• Target Antigen:

  Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-s-s-ahpc-hydrochloride.html

• Purity:

  99.42

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C([C@H](C[C@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl

• Molecular Weight:

  467.02

• References & Citations:

  [1]Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. J Med Chem. 2018 Jan 25;61(2):583-598.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  2115897-23-7