(S,S,S)-AHPC (hydrochloride)

(S,S,S)-AHPC (hydrochloride)

• Alternative Name: (S,S,S)-VH032-NH2 (hydrochloride)
• CAS Number: 2115897-23-7
• UNSPSC Description: (S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC (Compound 27) is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein[1].
• Target Antigen: Ligands for E3 Ligase
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s-s-s-ahpc-hydrochloride.html
• Purity: 99.42
• Solubility: DMSO : 62.5 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: O=C([C@H](C[C@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
• Molecular Weight: 467.02
• References & Citations: [1]Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. J Med Chem. 2018 Jan 25;61(2):583-598.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen, away from moisture)
• Clinical Information: No Development Reported