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Sevelamer (hydrochloride)

CAT: 0804-HY-13995A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13995A-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin[1][2][3].
CAS Number
152751-57-0
UNSPSC
12352211
Hazard Statement
H412
Target
Autophagy; FXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Sevelamer-hydrochloride.html
Purity
98.0
Solubility
DMSO : < 1 mg/mL
Smiles
NCC(CC(CC)CNCC(O)CNCC(C)CC(CC)CN)CC.[m].Cl.[m].[c].[b].[a]
Molecular Formula
(C3H7N.C3H5ClO) x.xHCl
Molecular Weight
186.08 (monomer)
Precautions
H412
References & Citations
[1]Sevelamer, From Wikipedia|[2]Bennis Y, et al. The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Toxins (Basel) . 2019 May 17;11 (5) :279. |[3]Susan C Schiavi, et al. Npt2b deletion attenuates hyperphosphatemia associated with CKD. J Am Soc Nephrol. 2012 Oct;23 (10) :1691-700.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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