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Il10 antibody

CAT: 0710-FNab10822Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10822Size:100 µg
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Background
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Synonyms
Interleukin family protein|Il10|IL-10
UniProt
G3HB01
Host
Rabbit
Reactivity
Hamster
Immunogen
Interleukin 10
Target
Il10
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology, Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
21 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · G3HB01

Interleukin family protein

G3HB01_CRIGR · Cricetulus griseus

View on UniProt ↗
Primary accession
G3HB01
Review status
UniProtKB unreviewed (TrEMBL)
Gene
Il10
Protein existence
3: Inferred from homology
Organism
Cricetulus griseus (Chinese hamster)
Taxonomy ID
10029
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Molecular function

Cytokine

PTM

Disulfide bond

Technical term

Reference proteome

Cellular component

Secreted

Domain

Signal

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