IL1B antibody

• Background :

  The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

• Synonyms :

  Interleukin-1 beta (IL-1 beta) |Catabolin|IL1B|IL1F2

• Gene ID :

  3553

• UniProt :

  P01584

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Interleukin 1, beta

• Target :

  IL1B

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, IHC, WB

• Field of Research :

  Neuroscience, Immunology, Cardiovascular, Signal Transduction

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  17, 35-40 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, IHC, WB

• Immunogen Sequence :

  70-170aa