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IL1B antibody

CAT: 0710-FNab04210Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04210Size:100 µg
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Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Synonyms
Interleukin-1 beta (IL-1 beta) |Catabolin|IL1B|IL1F2
Gene ID
3553
UniProt
P01584
Host
Mouse
Reactivity
Human
Immunogen
Interleukin 1, beta
Target
IL1B
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, IHC, WB
Field of Research
Neuroscience, Immunology, Cardiovascular, Signal Transduction
Purification
Protein G purified
Dilution
WB: 1:1000-1:4000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
35 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9G5
Tested Applications
ELISA, IHC, WB
Immunogen Sequence
117-269aa

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