Jingzhaotoxin-XII (TFA)

Jingzhaotoxin-XII (TFA)

• UNSPSC Description: Jingzhaotoxin-XII (JzTx-XII) TFA is a specific Kv4.1 channel inhibitor with an IC50 of 0.363 μM. Jingzhaotoxin-XII TFA interacts with the channels by modifying the gating behavior[1].
• Target Antigen: Potassium Channel
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/jingzhaotoxin-xii-tfa.html
• Purity: 95.06
• Solubility: H2O : ≥ 100 mg/mL
• Smiles: O=C([C@@H](N)CC1=CC=C(O)C=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CC(N)=O)=O)CC4=CC=C(O)C=C4)=O)CCCCN)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CO)=O)CC(O)=O)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N[C@H]3CC6=CNC7=CC=CC=C67)=O)CC(C)C)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)CC8=CNC9=CC=CC=C89)=O)CCSC)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)CCCCN)=O)CCC(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]5C(C)C)=O)CC%12=CC=C(O)C=C%12)=O)=O)CCC(O)=O)=O.O=C(O)C(F)(F)F.[x]
• Molecular Weight: 3665.23 (free base)
• References & Citations: [1]Yuan C, et al. Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. Toxicon. 2007 Oct;50(5):646-52.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported