Jingzhaotoxin XI

Jingzhaotoxin XI

• UNSPSC Description: Jingzhaotoxin XI (JZTX-XI) is a sodium conductance inhibitor with an IC50 of 124 nM. Jingzhaotoxin XI slows the fast inactivation (EC50=1.18±0.2 μM) of Nav1.5 expressed in Chinese hamster ovary (CHO-K1) cells[1].
• Target Antigen: Sodium Channel
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/jingzhaotoxin-xi.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(C)C)C(NC2)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H](CC4=CC=CC=C4)C(NCC(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N5[C@@H](CCC5)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@H]6CC7=CC=C(C=C7)O)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@H]3CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC%10=CC=CC=C%10)C(N)=O)=O)=O)=O)=O)=O)=O)NC6=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
• Molecular Weight: 3726.27
• References & Citations: [1]Tang C, et al. The tarantula toxin jingzhaotoxin-XI (κ-theraphotoxin-Cj1a) regulates the activation and inactivation of the voltage-gated sodium channel Nav1.5. Toxicon. 2014 Dec 15;92:6-13.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported