Jingzhaotoxin-X

Jingzhaotoxin-X

• UNSPSC Description: Jingzhaotoxin-X (JZTX-X) is a selective Kv4.2 and Kv4.3 potassium channels inhibitor. Jingzhaotoxin-X causes long-lasting mechanical hyperalgesia[1].
• Target Antigen: Potassium Channel
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/jingzhaotoxin-x.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)NC2=O)C(N[C@@H](C)C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@H]4CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)NC6=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@H]2CC9=CNC=N9)=O)=O)=O)=O)=O)=O)NC4=O)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H]6CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
• Molecular Weight: 3706.35
• References & Citations: [1]Deng M, et al. Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao. J Venom Anim Toxins Incl Trop Dis. 2020 May 29;26:e20190043.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported