Lys-Nε-SPDB-DM4

• UNSPSC Description:

  Lys-Nε-SPDB-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody agent conjugate (ADC)[1].

• Target Antigen:

  Drug-Linker Conjugates for ADC

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lys-nε-spdb-dm4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCC(C)(C)SSCCCC(NCCCC[C@H](N)C(O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1

• Molecular Weight:

  1026.69

• References & Citations:

  [1]Hans K Erickson, et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res. 2006 Apr 15;66(8):4426-33.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported