sulfo-SPDB-DM4
CAT:
804-HY-101141-03
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: Yes

sulfo-SPDB-DM4
- CAS Number: 1626359-59-8
- UNSPSC Description: sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.
- Target Antigen: Drug-Linker Conjugates for ADC
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/sulfo-SPDB-DM4.html
- Purity: 99.97
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(S(=O)(O)=O)C(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1
- Molecular Weight: 1075.66
- References & Citations: [1]Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
- Shipping Conditions: Dry Ice
- Storage Conditions: -80°C, protect from light, stored under nitrogen
- Clinical Information: No Development Reported