ARC 239

• Description :

  ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  5-HT Receptor; Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/arc-239.html

• Purity :

  99.71

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O

• Molecular Formula :

  C24H29N3O3

• Molecular Weight :

  407.51

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]K T Gavin, et al. Alpha 2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355 (3) :406-11. |[2]J J Meana, et al. The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain. Eur J Pharmacol. 1996 Oct 3;312 (3) :385-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor; mLAG-3; α adrenergic receptor

• CAS Number :

  [67339-62-2]